A high positive end-expiratory pressure, low tidal volume ventilatory strategy improves outcome in persistent acute respiratory distress syndrome: A randomized, controlled trial*
Unidades Centrales Científico-Técnicas · St. Michael's Hospital · +3 more institutions
Abstract
It has been shown in a two-center study that high positive end-expiratory pressure (PEEP) and low tidal volume (LTV) improved outcome in ARDS. However, that study involved patients with underlying diseases unique to the study area, was conducted at only two centers, and enrolled a small number of patients. We similarly hypothesized that a ventilatory strategy based on PEEP above the lower inflection point of the pressure volume curve of the respiratory system (Pflex) set on day 1 with a low tidal volume would result in improved outcome in patients with severe and persistent acute respiratory distress syndrome (ARDS).
Randomized, controlled clinical trial.
Citation impact
- FWCI
- 41.09
- Percentile
- 100%
- References
- 35
Authors
4- JVJesús VillarCorresponding
Unidades Centrales Científico-Técnicas, St. Michael's Hospital, Canary Institute of Cancer Research, Consejo Superior de Investigaciones Científicas
- RMRobert M. Kacmarek
American Academy for Jewish Research, Consejo Superior de Investigaciones Científicas, Canary Institute of Cancer Research, Unidades Centrales Científico-Técnicas, St. Michael's Hospital
- LPLina Pérez‐Méndez
Canary Institute of Cancer Research, American Academy for Jewish Research, St. Michael's Hospital, Unidades Centrales Científico-Técnicas, Consejo Superior de Investigaciones Científicas
- AAArmando Aguirre‐Jaime
St. Michael's Hospital, American Academy for Jewish Research, Canary Institute of Cancer Research, Consejo Superior de Investigaciones Científicas, Unidades Centrales Científico-Técnicas
Topics & keywords
- Medicine
- Positive end-expiratory pressure
- Randomized controlled trial
- Positive-Pressure Respiration
- Acute respiratory distress
- Tidal volume
- Respiratory distress
- Anesthesia