Worldwide Human Papillomavirus Etiology of Cervical Adenocarcinoma and Its Cofactors: Implications for Screening and Prevention
Vrije Universiteit Amsterdam · Health Canada · +6 more institutions
Abstract
Most cancers of the uterine cervix are squamous cell carcinomas. Although the incidence of such carcinomas of the uterine cervix has declined over time, that of cervical adenocarcinoma has risen in recent years. The extent to which human papillomavirus (HPV) infection and cofactors may explain this differential trend is unclear.
We pooled data from eight case-control studies of cervical cancer that were conducted on three continents. A total of 167 case patients with invasive cervical adenocarcinoma (112 with adenocarcinoma and 55 with adenosquamous carcinoma) and 1881 hospital-based control subjects were included. HPV DNA was analyzed in cervical specimens with the GP5+/6+ general primer system followed by type-specific hybridization for 33 HPV genotypes. Blood samples were analyzed for chlamydial and herpes simplex virus 2 (HSV-2) serology. Multivariable unconditional logistic regression modeling was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs). All tests of statistical significance were two-sided.
Citation impact
- FWCI
- 36.16
- Percentile
- 100%
- References
- 67
Authors
12- XCXavier CastellsaguéCorresponding
Vrije Universiteit Amsterdam, Health Canada, Institut Català d'Oncologia, University of North Carolina at Chapel Hill, Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud, Centre International de Recherche sur le Cancer, University of Washington, Institut d'Investigació Biomédica de Bellvitge
- MDMireia Díaz
University of North Carolina at Chapel Hill, Health Canada, Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud, Institut d'Investigació Biomédica de Bellvitge, University of Washington, Centre International de Recherche sur le Cancer, Institut Català d'Oncologia, Vrije Universiteit Amsterdam
- SDSílvia de Sanjosé
Vrije Universiteit Amsterdam, University of Washington, Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud, Centre International de Recherche sur le Cancer, University of North Carolina at Chapel Hill, Institut Català d'Oncologia, Institut d'Investigació Biomédica de Bellvitge, Health Canada
- NMNúbia Muñóz
Centre International de Recherche sur le Cancer, Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud, Vrije Universiteit Amsterdam, Institut d'Investigació Biomédica de Bellvitge, University of Washington, Institut Català d'Oncologia, Health Canada, University of North Carolina at Chapel Hill
- RHRolando Herrero
Vrije Universiteit Amsterdam, University of North Carolina at Chapel Hill, Health Canada, Centre International de Recherche sur le Cancer, University of Washington, Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud, Institut Català d'Oncologia, Institut d'Investigació Biomédica de Bellvitge
Topics & keywords
- Medicine
- Cervical cancer
- Adenocarcinoma
- Odds ratio
- Cervix
- Obstetrics
- Oncology
- Gynecology
- Good health and well-being