Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via β-adrenergic induction of myelopoiesis
The Ohio State University · Salk Institute for Biological Studies · +4 more institutions
Abstract
Across a variety of adverse life circumstances, such as social isolation and low socioeconomic status, mammalian immune cells have been found to show a conserved transcriptional response to adversity (CTRA) involving increased expression of proinflammatory genes. The present study examines whether such effects might stem in part from the selective up-regulation of a subpopulation of immature proinflammatory monocytes (Ly-6c(high) in mice, CD16(-) in humans) within the circulating leukocyte pool. Transcriptome representation analyses showed relative expansion of the immature proinflammatory monocyte transcriptome in peripheral blood mononuclear cells from people subject to chronic social stress (low…
Citation impact
- FWCI
- 12.61
- Percentile
- 100%
- References
- 67
Authors
10- NPNicole PowellCorresponding
The Ohio State University
- EKErica K. Sloan
Salk Institute for Biological Studies, University of California, Los Angeles
- MTMichael T. Bailey
Institute for Behavioral Medicine, The Ohio State University
- JMJesusa M.G. Arevalo
University of California, Los Angeles
- GEGregory E. Miller
Northwestern University
Topics & keywords
- Proinflammatory cytokine
- Myelopoiesis
- Transcriptome
- Context (archaeology)
- Receptor
- Immunology
- Chronic stress
- Gene expression