Osteosarcoma: Current Treatment and a Collaborative Pathway to Success
Center for Cancer and Blood Disorders
Abstract
Osteosarcoma is the bone tumor that most commonly affects children, adolescents, and young adults. Before 1970, treatment primarily included surgical resection. However, the introduction of chemotherapy led to a dramatic improvement in prognosis for patients with localized osteosarcoma; long-term survival rates of less than 20% improved to 65% to 70% after the advent of multiagent chemotherapy regimens. Controversy concerning the ideal combination of chemotherapy agents ensued throughout the last quarter of the 20th century because of conflicting and often nonrandomized data. However, large cooperative group studies and international collaboration have demonstrated that the most effective regimens include the…
Citation impact
- FWCI
- 60.38
- Percentile
- 100%
- References
- 59
Authors
4Topics & keywords
- Medicine
- Osteosarcoma
- Ifosfamide
- Chemotherapy
- Oncology
- Methotrexate
- Cisplatin
- Clinical trial