Fibroblast heterogeneity in the cancer wound
Indexed incrossrefpubmed
Abstract
Fibroblasts regulate the structure and function of healthy tissues, participate transiently in tissue repair after acute inflammation, and assume an aberrant stimulatory role during chronic inflammatory states including cancer. Such cancer-associated fibroblasts (CAFs) modulate the tumor microenvironment and influence the behavior of neoplastic cells in either a tumor-promoting or tumor-inhibiting manner. These pleiotropic functions highlight the inherent plasticity of fibroblasts and may provide new avenues to understand and therapeutically intervene in malignancies. We discuss the emerging themes of CAF biology in the context of tumorigenesis and therapy.
Citation impact
909
total citations
- FWCI
- 27.45
- Percentile
- 100%
- References
- 278
Citations per year
Authors
3Topics & keywords
Topics
Keywords
- Carcinogenesis
- Cancer-Associated Fibroblasts
- Tumor microenvironment
- Context (archaeology)
- Cancer research
- Fibroblast
- Inflammation
- Cancer
UN Sustainable Development Goals
- Good health and well-being
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Funding
- UDU.S. Department of DefenseAwards: W81XWH, W81XWH-13-PRCRP-IA, W81XWH-13
- LFLustgarten FoundationAwards: 5P50CA101955, 5P30CA45508
- SFStarr FoundationAward: I7-A718
- PCPancreatic Cancer UK
- KFKempe Foundation
- WIWeizmann Institute of Science
- VVetenskapsrådetAward: 537-2013-7277
- KKempestiftelsernaAward: JCK-1301
- SLSvenska LäkaresällskapetAwards: SLS-326921, SLS-250831
- NINational Institutes of HealthAwards: 1U10CA180944, 5P30CA45508-26, 5P50CA101955-07, W81XWH, 5P50CA101955, 5U01CA168409-3, 5P30CA45508, 1U10CA180944-01
- DPDOD Peer Reviewed Cancer Research Program