PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition
Beth Israel Deaconess Medical Center · Howard Hughes Medical Institute · +3 more institutions
Abstract
UNLABELLED: Prions are self-templating protein aggregates that stably perpetuate distinct biological states and are of keen interest to researchers in both evolutionary and biomedical science. The best understood prions are from yeast and have a prion-forming domain with strongly biased amino acid composition, most notably enriched for Q or N. PLAAC is a web application that scans protein sequences for domains with P: rion- L: ike A: mino A: cid C: omposition. Users can upload sequence files, or paste sequences directly into a textbox. PLAAC ranks the input sequences by several summary scores and allows scores along sequences to be visualized. Text output files can be downloaded for further analyses, and…
Citation impact
- FWCI
- 4.69
- Percentile
- 100%
- References
- 8
Authors
4- AKAlex K. Lancaster
Beth Israel Deaconess Medical Center, Howard Hughes Medical Institute, Harvard University, University of Massachusetts Chan Medical School, Whitehead Institute for Biomedical Research
- ANAndrew Nutter-Upham
Beth Israel Deaconess Medical Center, Howard Hughes Medical Institute, Harvard University, University of Massachusetts Chan Medical School, Whitehead Institute for Biomedical Research
- SLSusan LindquistCorresponding
Beth Israel Deaconess Medical Center, Howard Hughes Medical Institute, Harvard University, University of Massachusetts Chan Medical School, Whitehead Institute for Biomedical Research
- ODOliver D. KingCorresponding
Beth Israel Deaconess Medical Center, Howard Hughes Medical Institute, Harvard University, University of Massachusetts Chan Medical School, Whitehead Institute for Biomedical Research
Topics & keywords
- Computer science
- Upload
- Software
- Visualization
- Domain (mathematical analysis)
- Composition (language)
- Unix
- Line (geometry)