Allenes in Catalytic Asymmetric Synthesis and Natural Product Syntheses

Allenes are the simplest class of cumulenes, with two contiguous C=C bonds, and show unique physical and chemical properties. These features make allenes particularly attractive in modern organic chemistry. In this Review, attention is paid to the advances made in catalytic asymmetric synthesis and natural product syntheses based on well-established reactions of allenes, such as propargylation, addition, cycloaddition, cycloisomerization, cyclization, etc., with or without catalysts. Their versatile reactivity, substituent-loading ability, axial to center chirality transfer, and controllable selectivity allow access to target molecules by unique and efficient approaches. The main topics in this Review are…

• NS
  National Science Foundation
• NN
  National Natural Science Foundation of China

  Award: 20732005
• EC
  East China Normal University
• SI
  Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences