articleBioinformaticsSep 8, 2008BRONZE OA

ADZE: a rarefaction approach for counting alleles private to combinations of populations

ZAZachary A. SzpiechMJMattias JakobssonNANoah A. Rosenberg

Uppsala University · University of Michigan

PubMed
Indexed incrossrefdoajpubmed

Abstract

MOTIVATION: Analysis of the distribution of alleles across populations is a useful tool for examining population diversity and relationships. However, sample sizes often differ across populations, sometimes making it difficult to assess allelic distributions across groups. RESULTS: We introduce a generalized rarefaction approach for counting alleles private to combinations of populations. Our method evaluates the number of alleles found in each of a set of populations but absent in all remaining populations, considering equal-sized subsamples from each population. Applying this method to a worldwide human microsatellite dataset, we observe a high number of alleles private to the combination of African and…

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Topics & keywords

Topics
Keywords
  • Allele
  • Population
  • Sample (material)
  • Rarefaction (ecology)
  • Biology
  • Diversity (politics)
  • Microsatellite
  • Set (abstract data type)
UN Sustainable Development Goals
  • Reduced inequalities
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