Brain-Derived Neurotrophic Factor Produces Antidepressant Effects in Behavioral Models of Depression
Yale University · Connecticut Mental Health Center
Abstract
Previous studies demonstrated that antidepressant treatment increases the expression of brain-derived neurotrophic factor (BDNF) in rat hippocampus. The present study was conducted to test the hypothesis that BDNF in the hippocampus produces an antidepressant effect in behavioral models of depression, the learned helplessness (LH) and forced swim test (FST) paradigms. A single bilateral infusion of BDNF into the dentate gyrus of hippocampus produced an antidepressant effect in both the LH and FST that was comparable in magnitude with repeated systemic administration of a chemical antidepressant. These effects were observed as early as 3 d after a single infusion of BDNF and lasted for at least 10 d. Similar…
Citation impact
- FWCI
- 20.74
- Percentile
- 100%
- References
- 45
Authors
5- YSYukihiko ShirayamaCorresponding
Yale University, Connecticut Mental Health Center
- ACAndrew C. H. Chen
Yale University, Connecticut Mental Health Center
- SNShin Nakagawa
Yale University, Connecticut Mental Health Center
- DRDavid Russell
Yale University, Connecticut Mental Health Center
- RSRonald S. Duman
Yale University, Connecticut Mental Health Center
Topics & keywords
- Behavioural despair test
- Antidepressant
- Brain-derived neurotrophic factor
- Dentate gyrus
- Neurotrophic factors
- Learned helplessness
- Hippocampus
- Psychology
- Good health and well-being