Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk
University of Regensburg · King's College London · +5 more institutions
Abstract
Age-related macular degeneration (AMD) is a multifactorial disease and a prevalent cause of visual impairment in developed countries. Risk factors include environmental components and genetic determinants. The complement factor H (CFH) has been the first major susceptibility gene for AMD identified within 1q32. Here, we focused on a second region of interest in 10q26 where a recent meta-analysis revealed strongest evidence for linkage to AMD at a genome-wide significance level. Within an interval of 22 Mb, we have analyzed 93 single nucleotide polymorphisms for allelic association with AMD in two independent case-control cohorts of German origin (AMD(combined) n=1166; controls(combined) n=945). Significant…
Citation impact
- FWCI
- 51.39
- Percentile
- 100%
- References
- 48
Authors
7- ARAndrea RiveraCorresponding
University of Regensburg
- SFSheila Fisher
King's College London, King's College School
- LGLars G. Fritsche
University of Regensburg
- CNClaudia N. Keilhauer
University of Würzburg
- PLPeter Lichtner
Center for Environmental Health, Technical University of Munich, Helmholtz Zentrum München
Topics & keywords
- Macular degeneration
- Disease
- Factor H
- Complement (music)
- Factor (programming language)
- Risk factor
- Complement factor B
- Degeneration (medical)
- Partnerships for the goals