Chimpanzee Reservoirs of Pandemic and Nonpandemic HIV-1

Keele, Brandon F.; Heuverswyn, Fran Van; Li, Yingying; Bailes, Elizabeth; Takehisa, Jun; Santiago, Mario L.; Bibollet‐Ruche, Frédéric; Chen, Yalu; Wain, Louise V.; Liégeois, Florian; Loul, Sévérin; Ngole, Eitel Mpoudi; Bienvenue, Yanga; Delaporte, Éric; Brookfield, John F. Y.; Sharp, Paul M.; Shaw, George M.; Peeters, Martine; Hahn, Beatrice H.

doi:10.1126/science.1126531

articleScienceMay 25, 2006GREEN OA

Chimpanzee Reservoirs of Pandemic and Nonpandemic HIV-1

BFBrandon F. Keele FVFran Van Heuverswyn YLYingying Li EBElizabeth Bailes JTJun Takehisa

Howard Hughes Medical Institute · University of Nottingham · +4 more institutions

PubMed

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Abstract

Human immunodeficiency virus type 1 (HIV-1), the cause of human acquired immunodeficiency syndrome (AIDS), is a zoonotic infection of staggering proportions and social impact. Yet uncertainty persists regarding its natural reservoir. The virus most closely related to HIV-1 is a simian immunodeficiency virus (SIV) thus far identified only in captive members of the chimpanzee subspecies Pan troglodytes troglodytes. Here we report the detection of SIVcpz antibodies and nucleic acids in fecal samples from wild-living P. t. troglodytes apes in southern Cameroon, where prevalence rates in some communities reached 29 to 35%. By sequence analysis of endemic SIVcpz strains, we could trace the origins of pandemic (group…

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Topics & keywords

Topics

Keywords

Troglodytes
Subspecies
Simian immunodeficiency virus
Biology
Pandemic
Virology
Simian
Virus

UN Sustainable Development Goals

Good health and well-being

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