Clinical Impact of Different Classes of Infiltrating T Cytotoxic and Helper Cells (Th1, Th2, Treg, Th17) in Patients with Colorectal Cancer
Inserm · Université Paris Cité · +3 more institutions
Abstract
The tumor microenvironment includes a complex network of immune T-cell subpopulations. In this study, we systematically analyzed the balance between cytotoxic T cells and different subsets of helper T cells in human colorectal cancers and we correlated their impact on disease-free survival. A panel of immune related genes were analyzed in 125 frozen colorectal tumor specimens. Infiltrating cytotoxic T cells, Treg, Th1, and Th17 cells were also quantified in the center and the invasive margin of the tumors. By hierarchical clustering of a correlation matrix we identified functional clusters of genes associated with Th17 (RORC, IL17A), Th2 (IL4, IL5, IL13), Th1 (Tbet, IRF1, IL12Rb2, STAT4), and cytotoxicity…
Citation impact
- FWCI
- 33.64
- Percentile
- 100%
- References
- 38
Authors
11- MTMarie TosoliniCorresponding
Inserm, Université Paris Cité, Sorbonne Université, Assistance Publique – Hôpitaux de Paris, Hôpital Européen Georges-Pompidou
- AKAmos Kirilovsky
Inserm, Université Paris Cité, Sorbonne Université, Assistance Publique – Hôpitaux de Paris, Hôpital Européen Georges-Pompidou
- BMBernhard Mlecnik
Inserm, Université Paris Cité, Sorbonne Université, Assistance Publique – Hôpitaux de Paris, Hôpital Européen Georges-Pompidou
- TFTessa Fredriksen
Inserm, Université Paris Cité, Sorbonne Université, Assistance Publique – Hôpitaux de Paris, Hôpital Européen Georges-Pompidou
- SMStéphanie Mauger
Inserm, Université Paris Cité, Sorbonne Université, Assistance Publique – Hôpitaux de Paris, Hôpital Européen Georges-Pompidou
Topics & keywords
- Cytotoxic T cell
- Immune system
- Colorectal cancer
- CD8
- RAR-related orphan receptor gamma
- Immunology
- Tumor microenvironment
- Biology
- Reduced inequalities