Inferring the human microRNA functional similarity and functional network based on microRNA-associated diseases
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Abstract
MOTIVATION: It is popular to explore meaningful molecular targets and infer new functions of genes through gene functional similarity measuring and gene functional network construction. However, little work is available in this field for microRNA (miRNA) genes due to limited miRNA functional annotations. With the rapid accumulation of miRNAs, it is increasingly needed to uncover their functional relationships in a systems level. RESULTS: It is known that genes with similar functions are often associated with similar diseases, and the relationship of different diseases can be represented by a structure of directed acyclic graph (DAG). This is also true for miRNA genes. Therefore, it is feasible to infer miRNA…
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5Topics & keywords
Topics
Keywords
- microRNA
- Computational biology
- Similarity (geometry)
- Pairwise comparison
- Biology
- Gene
- Bioinformatics
- Computer science
UN Sustainable Development Goals
- Life in Land
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