Oxidative Stress and the Pathogenesis of Alzheimer's Disease
Harbin Institute of Technology · Chinese Academy of Sciences · +1 more institution
Abstract
Alzheimer's disease (AD) is the most common neurodegenerative disease that causes dementia in the elderly. Patients with AD suffer a gradual deterioration of memory and other cognitive functions, which eventually leads to a complete incapacity and death. A complicated array of molecular events has been implicated in the pathogenesis of AD. The major pathological characteristics of AD brains are the presence of senile plaques, neurofibrillary tangles, and neuronal loss. Growing evidence has demonstrated that oxidative stress is an important factor contributing to the initiation and progression of AD. However, the mechanisms that lead to the disruption of redox balance and the sources of free radicals remain…
Citation impact
- FWCI
- 26.07
- Percentile
- 100%
- References
- 141
Authors
2Topics & keywords
- Oxidative stress
- Senile plaques
- Pathogenesis
- Neurotoxicity
- Oxidative phosphorylation
- Reactive oxygen species
- Dementia
- Alzheimer's disease
Funding
- NNNational Natural Science Foundation of ChinaAwards: HIT(WH)Y200902, 2011DXGJ14, 2009-3-93, 30930036, 30870587, 31201338, 2006CB500706, 2009147, Y200902
- HIHarbin Institute of TechnologyAwards: 2009147, 30930036, HIT(WH)Y200902, 2006CB500706, Y200902, 2009-3-93, 30870587, 2011DXGJ14, 31201338
- WSWeihai Science and Technology Development ProgramAwards: 2011DXGJ14, 2006CB500706, Y200902, 30870587, 30930036, 31201338, 2009147, 2009-3-93
- NKNational Key Research and Development Program of ChinaAwards: 2009-3-93, 31201338, Y200902, 2006CB500706, 2011DXGJ14, 30930036, 2009147, 30870587
- FRFundamental Research Funds for the Central Universities