The prognostic influence of tumour-infiltrating lymphocytes in cancer: a systematic review with meta-analysis
University Medical Center Groningen · University of Groningen · +1 more institution
Abstract
Tumour-infiltrating lymphocytes (TILs) are often found in tumours, presumably reflecting an immune response against the tumour. We carried out a systematic review and meta-analysis, aiming to establish pooled estimates for survival outcomes based on the presence of TILs in cancer.
A Pubmed and Embase literature search was designed. Studies were included, in which the prognostic significance of intratumoural CD3+, CD4+, CD8+, and FoxP3+ lymphocytes, as well as ratios between these subsets, were determined in solid tumours.
Citation impact
- FWCI
- 15.33
- Percentile
- 100%
- References
- 81
Authors
5- MJMarloes J.M. GoodenCorresponding
- GHGeertruida H. de Bock
University Medical Center Groningen, University of Groningen
- NLNinke Leffers
Target (United States), University Medical Center Groningen, University of Groningen
- TDToos Daemen
Target (United States), University Medical Center Groningen, University of Groningen
- HWHans W. Nijman
Target (United States), University Medical Center Groningen, University of Groningen
Topics & keywords
- Tumor-infiltrating lymphocytes
- Hazard ratio
- Meta-analysis
- FOXP3
- Medicine
- Oncology
- Context (archaeology)
- Internal medicine
- Good health and well-being