The Nalp3 inflammasome is essential for the development of silicosis
University of Iowa · American College of Allergy, Asthma and Immunology · +5 more institutions
Abstract
Inhalation of crystalline silica and asbestos is known to cause the progressive pulmonary fibrotic disorders silicosis and asbestosis, respectively. Although alveolar macrophages are believed to initiate these inflammatory responses, the mechanism by which this occurs has been unclear. Here we show that the inflammatory response and subsequent development of pulmonary fibrosis after inhalation of silica is dependent on the Nalp3 inflammasome. Stimulation of macrophages with silica results in the activation of caspase-1 in a Nalp3-dependent manner. Macrophages deficient in components of the Nalp3 inflammasome were incapable of secreting the proinflammatory cytokines interleukin (IL)-1beta and IL-18 in response…
Citation impact
- FWCI
- 50.85
- Percentile
- 100%
- References
- 31
Authors
10- SLSuzanne L. CasselCorresponding
University of Iowa, American College of Allergy, Asthma and Immunology
- SCStephanie C. Eisenbarth
Yale University
- SSShankar S. Iyer
University of Iowa, Office of Infectious Diseases, Inflammation Research Foundation
- JJJeffrey J. Sadler
University of Iowa, Office of Infectious Diseases, Inflammation Research Foundation
- OROscar R. Colegio
Yale University
Topics & keywords
- NALP3
- Inflammasome
- Caspase 1
- Silicosis
- Proinflammatory cytokine
- AIM2
- Pathogenesis
- Pneumoconiosis