EXTENT OF RESECTION AND SURVIVAL IN GLIOBLASTOMA MULTIFORME
Goethe University Frankfurt · Gesellschaft für Klinische Forschung · +6 more institutions
Abstract
The influence of the degree of resection on survival in patients with glioblastoma multiforme is still under discussion. The highly controlled 5-aminolevulinic acid study provided a unique platform for addressing this question as a result of the high frequency of "complete" resections, as revealed by postoperative magnetic resonance imaging scans achieved by fluorescence-guided resection and homogeneous patient characteristics.
Two hundred forty-three patients with glioblastoma multiforme per protocol from the 5-aminolevulinic acid study were analyzed. Patients with complete and incomplete resections as revealed by early magnetic resonance imaging scans were compared. Prognostic factors that might cause bias regarding resection and influence survival (e.g., tumor size, edema, midline shift, location, age, Karnofsky Performance Scale score, National Institutes of Health Stroke Scale score) were used for analysis of overall survival. Time to reintervention (chemotherapy, reoperation) was analyzed further to exclude bias regarding second-line therapies.
Citation impact
- FWCI
- 21.19
- Percentile
- 100%
- References
- 19
Authors
12- WSWalter StummerCorresponding
Goethe University Frankfurt, Gesellschaft für Klinische Forschung, University Hospital Frankfurt, Medac (Germany), Heinrich Heine University Düsseldorf, Charité - Universitätsmedizin Berlin, Ludwig-Maximilians-Universität München, RWTH Aachen University
- HJH. J. Reulen
Goethe University Frankfurt, Gesellschaft für Klinische Forschung, University Hospital Frankfurt, Medac (Germany), Heinrich Heine University Düsseldorf, Charité - Universitätsmedizin Berlin, Ludwig-Maximilians-Universität München, RWTH Aachen University
- TRThomas R. Meinel
Goethe University Frankfurt, Gesellschaft für Klinische Forschung, University Hospital Frankfurt, Medac (Germany), Heinrich Heine University Düsseldorf, Charité - Universitätsmedizin Berlin, Ludwig-Maximilians-Universität München, RWTH Aachen University
- UPUwe Pichlmeier
Goethe University Frankfurt, Gesellschaft für Klinische Forschung, University Hospital Frankfurt, Medac (Germany), Heinrich Heine University Düsseldorf, Charité - Universitätsmedizin Berlin, Ludwig-Maximilians-Universität München, RWTH Aachen University
- WSWiebke Schumacher
Goethe University Frankfurt, Gesellschaft für Klinische Forschung, University Hospital Frankfurt, Medac (Germany), Heinrich Heine University Düsseldorf, Charité - Universitätsmedizin Berlin, Ludwig-Maximilians-Universität München, RWTH Aachen University
Topics & keywords
- Medicine
- Glioblastoma
- Magnetic resonance imaging
- Surgery
- Brain tumor
- Karnofsky Performance Status
- Multivariate analysis
- Radiology
- Good health and well-being