Association between Microdeletion and Microduplication at 16p11.2 and Autism
Autism Consortium · Harvard University Press · +4 more institutions
Abstract
Autism spectrum disorder is a heritable developmental disorder in which chromosomal abnormalities are thought to play a role.
As a first component of a genomewide association study of families from the Autism Genetic Resource Exchange (AGRE), we used two novel algorithms to search for recurrent copy-number variations in genotype data from 751 multiplex families with autism. Specific recurrent de novo events were further evaluated in clinical-testing data from Children's Hospital Boston and in a large population study in Iceland.
Citation impact
- FWCI
- 116.86
- Percentile
- 100%
- References
- 17
Authors
22- LALauren A. WeissCorresponding
Autism Consortium
- YSYiping Shen
Harvard University Press, Center for Autism and Related Disorders
- JMJoshua M. Korn
Harvard University Press, Massachusetts Institute of Technology, Center for Autism and Related Disorders
- DEDan E. Arking
Center for Autism and Related Disorders
- DTDavid T. Miller
Harvard University Press, Center for Autism and Related Disorders
Topics & keywords
- Medicine
- Autism
- Microdeletion syndrome
- Genetics
- Association (psychology)
- Autism spectrum disorder
- Psychiatry
- Biology