articleJournal of Clinical OncologyJan 19, 2005Closed access

Osteosarcoma Relapse After Combined Modality Therapy: An Analysis of Unselected Patients in the Cooperative Osteosarcoma Study Group (COSS)

BKBeate Kempf‐BielackSBStefan BielackHJHeribert JürgensDBD. BranscheidWEWolfgang E. Berdel

Düsseldorf University Hospital · Klinik und Poliklinik für Kinder- und Jugendmedizin · +3 more institutions

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Abstract

Purpose To evaluate the impact of patient, tumor, and treatment-related factors on outcome in unselected patients with recurrent osteosarcoma. Patients and Methods Five hundred seventy-six consecutive patients who had achieved a first complete surgical remission (CR) during combined-modality therapy on neoadjuvant Cooperative Osteosarcoma Study Group (COSS) protocols and then developed recurrent osteosarcoma were analyzed (median time from biopsy to relapse, 1.6 years; range, 0.1 to 14.3 years). There were 501 patients with metastases, 44 with local recurrences, and 31 with both. Metastases involved lungs (469 patients), bones (90 patients), and/or other sites (54 patients). Results After a median follow-up of…

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Topics & keywords

Topics
Keywords
  • Medicine
  • Osteosarcoma
  • Chemotherapy
  • Radiation therapy
  • Surgery
  • Multivariate analysis
  • Biopsy
  • Internal medicine
UN Sustainable Development Goals
  • Good health and well-being
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