The Mouse Retina as an Angiogenesis Model

The mouse retina has been used extensively over the past decades to study both physiologic and pathologic angiogenesis. Over time, various mouse retina models have evolved into well-characterized and robust tools for in vivo angiogenesis research. This article is a review of the angiogenic development of the mouse retina and a discussion of some of the most widely used vascular disease models. From the multitude of studies performed in the mouse retina, a selection of representative works is discussed in more detail regarding their role in advancing the understanding of both the ocular and general mechanisms of angiogenesis.

• JD
  Juvenile Diabetes Research Foundation International
• MO
  March of Dimes Foundation
• KT
  Knights Templar Eye Foundation
• RT
  Research to Prevent Blindness
• VK
  V. Kann Rasmussen Foundation

  Award: EY017017
• Ö
  Ögonfonden
• DF
  Deutsche Forschungsgemeinschaft
• NI
  National Institutes of Health

  Awards: P01 HD18655, EY017017
• MC
  Manton Center for Orphan Disease Research, Boston Children's Hospital
• CI
  Canadian Institutes of Health Research
• AR
  Alcon Research Institute