The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression
Universitat Pompeu Fabra · Institut thématique Génétique, génomique et bioinformatique · +12 more institutions
Abstract
The human genome contains many thousands of long noncoding RNAs (lncRNAs). While several studies have demonstrated compelling biological and disease roles for individual examples, analytical and experimental approaches to investigate these genes have been hampered by the lack of comprehensive lncRNA annotation. Here, we present and analyze the most complete human lncRNA annotation to date, produced by the GENCODE consortium within the framework of the ENCODE project and comprising 9277 manually annotated genes producing 14,880 transcripts. Our analyses indicate that lncRNAs are generated through pathways similar to that of protein-coding genes, with similar histone-modification profiles, splicing signals, and…
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Authors
27- TDThomas DerrienCorresponding
Universitat Pompeu Fabra, Institut thématique Génétique, génomique et bioinformatique, Centre for Genomic Regulation
- RJRory Johnson
Universitat Pompeu Fabra, Institut thématique Génétique, génomique et bioinformatique, Centre for Genomic Regulation
- GBGiovanni Bussotti
Universitat Pompeu Fabra, Institut thématique Génétique, génomique et bioinformatique, Centre for Genomic Regulation
- ATAndrea Tanzer
Universitat Pompeu Fabra, Institut thématique Génétique, génomique et bioinformatique, Centre for Genomic Regulation
- SDSarah Djebali
Universitat Pompeu Fabra, Institut thématique Génétique, génomique et bioinformatique, Centre for Genomic Regulation
Topics & keywords
- Biology
- Gene
- Human genome
- Genetics
- RNA splicing
- Genome
- ENCODE
- Computational biology