articlePLoS GeneticsJun 25, 2009GOLD OA

Assessing the Impact of Transgenerational Epigenetic Variation on Complex Traits

FJFrank JohannesEPEmmanuelle PorcherFKFelipe Karam TeixeiraVSVéra Saliba-ColombaniMSMatthieu Simon

Université Paris-Sud · Centre National de la Recherche Scientifique · +10 more institutions

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Abstract

Loss or gain of DNA methylation can affect gene expression and is sometimes transmitted across generations. Such epigenetic alterations are thus a possible source of heritable phenotypic variation in the absence of DNA sequence change. However, attempts to assess the prevalence of stable epigenetic variation in natural and experimental populations and to quantify its impact on complex traits have been hampered by the confounding effects of DNA sequence polymorphisms. To overcome this problem as much as possible, two parents with little DNA sequence differences, but contrasting DNA methylation profiles, were used to derive a panel of epigenetic Recombinant Inbred Lines (epiRILs) in the reference plant…

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Topics & keywords

Topics
Keywords
  • Transgenerational epigenetics
  • Biology
  • Epigenetics
  • Variation (astronomy)
  • Evolutionary biology
  • Genetics
  • Epigenesis
  • DNA methylation
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