Efficacy and Safety of Milrinone in Preventing Low Cardiac Output Syndrome in Infants and Children After Corrective Surgery for Congenital Heart Disease
Cincinnati Children's Hospital Medical Center · Boston Children's Hospital · +8 more institutions
Abstract
Background— Low cardiac output syndrome (LCOS), affecting up to 25% of neonates and young children after cardiac surgery, contributes to postoperative morbidity and mortality. This study evaluated the efficacy and safety of prophylactic milrinone in pediatric patients at high risk for developing LCOS. Methods and Results— The study was a double-blind, placebo-controlled trial with 3 parallel groups (low dose, 25-μg/kg bolus over 60 minutes followed by a 0.25-μg/kg per min infusion for 35 hours; high dose, 75-μg/kg bolus followed by a 0.75-μg/kg per min infusion for 35 hours; or placebo). The composite end point of death or the development of LCOS was evaluated at 36 hours and up to 30 days after randomization.…
Citation impact
- FWCI
- 19.18
- Percentile
- 100%
- References
- 16
Authors
12- TMTimothy M. HoffmanCorresponding
Cincinnati Children's Hospital Medical Center, Boston Children's Hospital, Children's Hospital of Philadelphia, Emory University, Medical University of South Carolina, University of Michigan, Sanofi (United States), Texas Children's Hospital, Boston Children's Museum, Covance (United States)
- GWGil Wernovsky
Cincinnati Children's Hospital Medical Center, Boston Children's Hospital, Children's Hospital of Philadelphia, Emory University, Medical University of South Carolina, University of Michigan, Sanofi (United States), Texas Children's Hospital, Boston Children's Museum, Covance (United States)
- AMAndrew M. Atz
Cincinnati Children's Hospital Medical Center, Boston Children's Hospital, Children's Hospital of Philadelphia, Emory University, Medical University of South Carolina, University of Michigan, Sanofi (United States), Texas Children's Hospital, Boston Children's Museum, Covance (United States)
- TJThomas J. Kulik
Cincinnati Children's Hospital Medical Center, Boston Children's Hospital, Children's Hospital of Philadelphia, Emory University, Medical University of South Carolina, University of Michigan, Sanofi (United States), Texas Children's Hospital, Boston Children's Museum, Covance (United States)
- DPDavid P. Nelson
Cincinnati Children's Hospital Medical Center, Boston Children's Hospital, Children's Hospital of Philadelphia, Emory University, Medical University of South Carolina, University of Michigan, Sanofi (United States), Texas Children's Hospital, Boston Children's Museum, Covance (United States)
Topics & keywords
- Milrinone
- Medicine
- Placebo
- Randomization
- Anesthesia
- Bolus (digestion)
- Heart disease
- Cardiac surgery
- Good health and well-being