Characterisation of COPD heterogeneity in the ECLIPSE cohort
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias · Thorax Foundation · +18 more institutions
Abstract
Chronic obstructive pulmonary disease (COPD) is a complex condition with pulmonary and extra-pulmonary manifestations. This study describes the heterogeneity of COPD in a large and well characterised and controlled COPD cohort (ECLIPSE).
We studied 2164 clinically stable COPD patients, 337 smokers with normal lung function and 245 never smokers. In these individuals, we measured clinical parameters, nutritional status, spirometry, exercise tolerance, and amount of emphysema by computed tomography.
Citation impact
- FWCI
- 51.74
- Percentile
- 100%
- References
- 32
Authors
15- TEthe Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) investigatorsCorresponding
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Thorax Foundation, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Universitat de Barcelona
- ÀAÀlvar Agustí
University of Liverpool, Aintree University Hospital, Hospital Clínic de Barcelona
- PMPeter M.A. Calverley
Brigham and Women's Hospital, University of Liverpool, Aintree University Hospital
- BRBartolomé R. Celli
Brigham and Women's Hospital, University of British Columbia, Vancouver General Hospital
- HOHarvey O. Coxson
Research Triangle Park Foundation, University of British Columbia, Vancouver General Hospital, GlaxoSmithKline (United States)
Topics & keywords
- COPD
- Medicine
- Spirometry
- Internal medicine
- Cohort
- Bronchiectasis
- Obstructive lung disease
- Pulmonary function testing