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TIGIT predominantly regulates the immune response via regulatory T cells
Brigham and Women's Hospital · QIMR Berghofer Medical Research Institute · +2 more institutions
Abstract
Coinhibitory receptors are critical for the maintenance of immune homeostasis. Upregulation of these receptors on effector T cells terminates T cell responses, while their expression on Tregs promotes their suppressor function. Understanding the function of coinhibitory receptors in effector T cells and Tregs is crucial, as therapies that target coinhibitory receptors are currently at the forefront of treatment strategies for cancer and other chronic diseases. T cell Ig and ITIM domain (TIGIT) is a recently identified coinhibitory receptor that is found on the surface of a variety of lymphoid cells, and its role in immune regulation is just beginning to be elucidated. We examined TIGIT-mediated immune…
Citation impact
- FWCI
- 14.03
- Percentile
- 100%
- References
- 46
Authors
9Topics & keywords
- TIGIT
- Immune system
- Cytotoxic T cell
- CD8
- Biology
- FOXP3
- Downregulation and upregulation
- T cell
- Good health and well-being
Funding
- CCConquer Cancer Foundation
- MRMelanoma Research Alliance
- BABrigham and Women's Hospital
- QBQIMR Berghofer Medical Research Institute
- NINational Institutes of HealthAwards: R01NS045937, P01AI073748, P01AI039671
- MRMedical Research Council
- NHNational Health and Medical Research CouncilAwards: 1093566, 1078671