Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
Délégation Paris 5 · Inserm · +7 more institutions
Abstract
The role of the adaptive immune response in controlling the growth and recurrence of human tumors has been controversial. We characterized the tumor-infiltrating immune cells in large cohorts of human colorectal cancers by gene expression profiling and in situ immunohistochemical staining. Collectively, the immunological data (the type, density, and location of immune cells within the tumor samples) were found to be a better predictor of patient survival than the histopathological methods currently used to stage colorectal cancer. The results were validated in two additional patient populations. These data support the hypothesis that the adaptive immune response influences the behavior of human tumors. In situ…
Citation impact
- FWCI
- 63.46
- Percentile
- 100%
- References
- 31
Authors
16- JGJérôme GalonCorresponding
Délégation Paris 5, Inserm, Université Paris Cité, Sorbonne Université, Graz University of Technology, Centre de Recherche des Cordeliers, Assistance Publique – Hôpitaux de Paris, Hôpital Européen Georges-Pompidou, Hôpital Avicenne
- ACAnne Costes
Délégation Paris 5, Inserm, Université Paris Cité, Sorbonne Université, Graz University of Technology, Centre de Recherche des Cordeliers, Assistance Publique – Hôpitaux de Paris, Hôpital Européen Georges-Pompidou, Hôpital Avicenne
- FSFátima Sánchez‐Cabo
Délégation Paris 5, Inserm, Université Paris Cité, Sorbonne Université, Graz University of Technology, Centre de Recherche des Cordeliers, Assistance Publique – Hôpitaux de Paris, Hôpital Européen Georges-Pompidou, Hôpital Avicenne
- AKAmos Kirilovsky
Délégation Paris 5, Inserm, Université Paris Cité, Sorbonne Université, Graz University of Technology, Centre de Recherche des Cordeliers, Assistance Publique – Hôpitaux de Paris, Hôpital Européen Georges-Pompidou, Hôpital Avicenne
- BMBernhard Mlecnik
Délégation Paris 5, Inserm, Université Paris Cité, Sorbonne Université, Graz University of Technology, Centre de Recherche des Cordeliers, Assistance Publique – Hôpitaux de Paris, Hôpital Européen Georges-Pompidou, Hôpital Avicenne
Topics & keywords
- Immune system
- Colorectal cancer
- Immunohistochemistry
- Biology
- Acquired immune system
- Tumor-infiltrating lymphocytes
- Cancer research
- Oncology
- Good health and well-being