Short-Term Neoadjuvant Androgen Deprivation Therapy and External-Beam Radiotherapy for Locally Advanced Prostate Cancer: Long-Term Results of RTOG 8610
University of Rochester Medical Center · University of California, Los Angeles · +5 more institutions
Abstract
Between 1987 and 1991, 456 assessable patients (median age, 70 years) were enrolled. Eligible patients had bulky (5 x 5 cm) tumors (T2-4) with or without pelvic lymph node involvement according to the 1988 American Joint Committee on Cancer TNM staging system. Patients received combined ADT that consisted of goserelin 3.6 mg every 4 weeks and flutamide 250 mg tid for 2 months before and concurrent with EBRT, or they received EBRT alone. Study end points included overall survival (OS), disease-specific mortality (DSM), distant metastasis (DM), disease-free survival (DFS), and biochemical failure (BF).
Ten-year OS estimates (43% v 34%) and median survival times (8.7 v 7.3 years) favored ADT and EBRT, respectively; however, these differences did not reach statistical significance (P = .12). There was a statistically significant improvement in 10-year DSM (23% v 36%; P = .01), DM (35% v 47%; P = .006), DFS (11% v 3%; P
Citation impact
- FWCI
- 46.20
- Percentile
- 100%
- References
- 33
Authors
10- MRMack RoachCorresponding
University of Rochester Medical Center
- KBKyounghwa Bae
University of California, Los Angeles, University of California, San Francisco, Thomas Jefferson University Hospital, Sutter Medical Center, University of Rochester Medical Center, Urology of Indiana, Indiana University – Purdue University Indianapolis
- JLJoycelyn L. Speight
University of California, Los Angeles, University of California, San Francisco, Thomas Jefferson University Hospital, Sutter Medical Center, University of Rochester Medical Center, Urology of Indiana, Indiana University – Purdue University Indianapolis
- HBHarvey B. Wolkov
University of California, Los Angeles, University of California, San Francisco, Thomas Jefferson University Hospital, Sutter Medical Center, University of Rochester Medical Center, Urology of Indiana, Indiana University – Purdue University Indianapolis
- PRPhillip Rubin
University of California, Los Angeles, University of California, San Francisco, Thomas Jefferson University Hospital, Sutter Medical Center, University of Rochester Medical Center, Urology of Indiana, Indiana University – Purdue University Indianapolis
Topics & keywords
- Medicine
- Androgen deprivation therapy
- Prostate cancer
- Radiation therapy
- External beam radiotherapy
- Flutamide
- Internal medicine
- Oncology
- Good health and well-being