Ageing and Parkinson's disease: Why is advancing age the biggest risk factor?
Newcastle University · Newcastle Hospitals - Campus for Ageing and Vitality · +1 more institution
Abstract
As the second most common age related neurodegenerative disease after Alzheimer's disease, the health, social and economic impact resulting from Parkinson's disease will continue to increase alongside the longevity of the population. Ageing remains the biggest risk factor for developing idiopathic Parkinson's disease. Although research into the mechanisms leading to cell death in Parkinson's disease has shed light on many aspects of the pathogenesis of this disorder, we still cannot answer the fundamental question, what specific age related factors predispose some individuals to develop this common neurodegenerative disease. In this review we focus specifically on the neuronal population associated with the…
Citation impact
- FWCI
- 30.92
- Percentile
- 100%
- References
- 148
Authors
3- AKAmy K. Reeve
Newcastle University, Newcastle Hospitals - Campus for Ageing and Vitality, Wellcome Centre for Mitochondrial Research
- EMEve M. Simcox
Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle Hospitals - Campus for Ageing and Vitality
- DMDouglass M. TurnbullCorresponding
Wellcome Centre for Mitochondrial Research, Newcastle Hospitals - Campus for Ageing and Vitality, Newcastle University
Topics & keywords
- Substantia nigra
- Disease
- Parkinson's disease
- Ageing
- Neuroscience
- Dopaminergic
- Population
- Population ageing