Late-life depression and risk of vascular dementia and Alzheimer's disease: systematic review and meta-analysis of community-based cohort studies
Universidade Federal de Minas Gerais · University of Pittsburgh
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Abstract
Background
Late-life depression may increase the risk of incident dementia, in particular of Alzheimer's disease and vascular dementia.
Aims
To conduct a systematic review and meta-analysis to evaluate the risk of incident all-cause dementia, Alzheimer's disease and vascular dementia in individuals with late-life depression in population-based prospective studies. METHOD: A total of 23 studies were included in the meta-analysis. We used the generic inverse variance method with a random-effects model to calculate the pooled risk of dementia, Alzheimer's disease and vascular dementia in older adults with late-life depression.
Citation impact
1,276
total citations
- FWCI
- 42.42
- Percentile
- 100%
- References
- 40
Citations per year
Authors
5Topics & keywords
Topics
Keywords
- Dementia
- Vascular dementia
- Late life depression
- Depression (economics)
- Medicine
- Meta-analysis
- Cohort study
- Disease
UN Sustainable Development Goals
- Good health and well-being
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Funding
- JAJohn A. Hartford Foundation
- HFHartford Foundation for Public Giving
- AFAmerican Foundation for Suicide Prevention
- NINational Institute on AgingAwards: UL1TR000005, RR024153
- NHNational Heart, Lung, and Blood InstituteAwards: UL1 RR024153, UL1TR000005
- NINational Institute of Mental HealthAwards: UL1 RR024153, UL1TR000005, P30 MH090333, MH080240, MH090333, R01 MH072947
- NINational Institute on Minority Health and Health Disparities