Biologic properties of mesenchymal stem cells derived from bone marrow and adipose tissue
Tulane University · Pennington Biomedical Research Center
Abstract
The biologic characteristics of mesenchymal stem cells (MSCs) isolated from two distinct tissues, bone marrow and adipose tissue were evaluated in these studies. MSCs derived from human and non-human primate (rhesus monkey) tissue sources were compared. The data indicate that MSCs isolated from rhesus bone marrow (rBMSCs) and human adipose tissue (hASCs) had more similar biologic properties than MSCs of rhesus adipose tissue (rASCs) and human bone marrow MSCs (hBMSCs). Analyses of in vitro growth kinetics revealed shorter doubling time for rBMSCs and hASCs. rBMSCs and hASCs underwent significantly more population doublings than the other MSCs. MSCs from all sources showed a marked decrease in telomerase…
Citation impact
- FWCI
- 13.97
- Percentile
- 100%
- References
- 52
Authors
7Topics & keywords
- Adipose tissue
- Mesenchymal stem cell
- Stem cell transplantation for articular cartilage repair
- Bone marrow
- Stem cell
- Clinical uses of mesenchymal stem cells
- Cell biology
- Biology