Exosomes: secreted vesicles and intercellular communications

Exosomes are small membrane vesicles of endocytic origin secreted by most cell types, and are thought to play important roles in intercellular communications. Although exosomes were originally described in 1983, interest in these vesicles has really increased dramatically in the last 3 years, after the finding that they contain mRNA and microRNA. This discovery sparked renewed interest for the general field of membrane vesicles involved in intercellular communications, and research on these structures has grown exponentially over the last few years, probing their composition and function, as well as their potential value as biomarkers.

• AN
  Agence Nationale de la Recherche
• IN
  Institut National de la Santé et de la Recherche Médicale
• FD
  Fondation de France
• IN
  Institut National Du Cancer