Default-mode network activity distinguishes Alzheimer's disease from healthy aging: Evidence from functional MRI

Recent functional imaging studies have revealed coactivation in a distributed network of cortical regions that characterizes the resting state, or default mode, of the human brain. Among the brain regions implicated in this network, several, including the posterior cingulate cortex and inferior parietal lobes, have also shown decreased metabolism early in the course of Alzheimer's disease (AD). We reasoned that default-mode network activity might therefore be abnormal in AD. To test this hypothesis, we used independent component analysis to isolate the network in a group of 13 subjects with mild AD and in a group of 13 age-matched elderly controls as they performed a simple sensory-motor processing task. Three…

• RK
  Ruth K. Broad Biomedical Research Foundation
• NI
  National Institutes of Health

  Awards: MH01142, HD31715