National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

Hyman, Bradley T.; Phelps, Creighton H.; Beach, Thomas G.; Bigio, Eileen H.; Cairns, Nigel J.; Carrillo, María C.; Dickson, Dennis W.; Duyckaerts, Charles; Frosch, Matthew P.; Masliah, Eliezer; Mirra, Suzanne S.; Nelson, Peter T.; Schneider, Julie A.; Thal, Dietmar Rudolf; Thies, Bill; Trojanowski, John Q.; Vinters, Harry V.; Montine, Thomas J.

doi:10.1016/j.jalz.2011.10.007

articleAlzheimer s & DementiaJan 1, 2012BRONZE OA

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

BTBradley T. Hyman CHCreighton H. Phelps TGThomas G. Beach EHEileen H. Bigio NJNigel J. Cairns

Harvard University · Massachusetts General Hospital · +16 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

A consensus panel from the United States and Europe was convened recently to update and revise the 1997 consensus guidelines for the neuropathologic evaluation of Alzheimer's disease (AD) and other diseases of brain that are common in the elderly. The new guidelines recognize the pre-clinical stage of AD, enhance the assessment of AD to include amyloid accumulation as well as neurofibrillary change and neuritic plaques, establish protocols for the neuropathologic assessment of Lewy body disease, vascular brain injury, hippocampal sclerosis, and TDP-43 inclusions, and recommend standard approaches for the workup of cases and their clinico-pathologic correlation.

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3,155

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Topics & keywords

Topics

Keywords

Senile plaques
Hippocampal sclerosis
Alzheimer's disease
Neuropathology
Disease
Medicine
Lewy body disease
Pathology

UN Sustainable Development Goals

Good health and well-being

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