articleAdvanced Functional MaterialsJul 9, 2012BRONZE OA

Hydrogel‐Forming Microneedle Arrays for Enhanced Transdermal Drug Delivery

RFRyan F. DonnellyTRThakur Raghu Raj SinghMJMartin J. GarlandKMKatarzyna MigalskaRMRita Majithiya

Queen's University Belfast · Queens University

PubMed
Indexed incrossrefpubmed

Abstract

Unique microneedle arrays prepared from crosslinked polymers, which contain no drug themselves, are described. They rapidly take up skin interstitial fluid upon skin insertion to form continuous, unblockable, hydrogel conduits from attached patch-type drug reservoirs to the dermal microcirculation. Importantly, such microneedles, which can be fabricated in a wide range of patch sizes and microneedle geometries, can be easily sterilized, resist hole closure while in place, and are removed completely intact from the skin. Delivery of macromolecules is no longer limited to what can be loaded into the microneedles themselves and transdermal drug delivery is now controlled by the crosslink density of the hydrogel…

Citation impact

685
total citations
FWCI
9.04
Percentile
100%
References
37
Citations per year

Authors

10

Topics & keywords

Topics
Keywords
  • Transdermal
  • Materials science
  • Stratum corneum
  • Drug delivery
  • Nanotechnology
  • Biomedical engineering
  • Drug
  • Pharmacology
UN Sustainable Development Goals
  • Industry, innovation and infrastructure
No related works found for this paper.

Funding