Prognostic Significance of Tumor Regression After Preoperative Chemoradiotherapy for Rectal Cancer
University of Göttingen · Friedrich-Alexander-Universität Erlangen-Nürnberg · +3 more institutions
Abstract
TRG 4, 3, 2, 1, 0 was found in 10.4%, 52.2%, 13.8%, 15.3%, and 8.3% of the resected specimens, respectively. Five-year disease-free survival (DFS) after CRT and curative resection was 86% for TRG 4, 75% for grouped TRG 2 + 3, and 63% for grouped TRG 0 + 1 (P = .006). On multivariate analysis, the pathologic T category and the nodal status after CRT were the most important independent prognostic factors for DFS.
In this exploratory analysis, complete (TRG 4) and intermediate pathologic response (TRG 2 + 3) suggested improved DFS after preoperative CRT. TRG assessment should be implemented in pathologic evaluation and prospectively validated in further studies.
Citation impact
- FWCI
- 17.32
- Percentile
- 100%
- References
- 35
Authors
11- CRClaus RödelCorresponding
University of Göttingen
- PMPeter Martus
Friedrich-Alexander-Universität Erlangen-Nürnberg, Advanced Radiation Therapy (United States), Kaiser-Franz-Josef-Spital, University of Rostock, University of Göttingen
- TPThomas Papadoupolos
Friedrich-Alexander-Universität Erlangen-Nürnberg, Advanced Radiation Therapy (United States), Kaiser-Franz-Josef-Spital, University of Rostock, University of Göttingen
- LFL. Füzesi
Friedrich-Alexander-Universität Erlangen-Nürnberg, Advanced Radiation Therapy (United States), Kaiser-Franz-Josef-Spital, University of Rostock, University of Göttingen
- MKM. Klimpfinger
Friedrich-Alexander-Universität Erlangen-Nürnberg, Advanced Radiation Therapy (United States), Kaiser-Franz-Josef-Spital, University of Rostock, University of Göttingen
Topics & keywords
- Medicine
- Grading (engineering)
- Colorectal cancer
- Chemoradiotherapy
- Multivariate analysis
- Internal medicine
- Carcinoma
- Univariate analysis
- Good health and well-being