Human Papillomavirus and Rising Oropharyngeal Cancer Incidence in the United States
National Cancer Institute · University of Southern California · +6 more institutions
Abstract
PURPOSE: Recent increases in incidence and survival of oropharyngeal cancers in the United States have been attributed to human papillomavirus (HPV) infection, but empirical evidence is lacking. PATIENTS AND METHODS: HPV status was determined for all 271 oropharyngeal cancers (1984-2004) collected by the three population-based cancer registries in the Surveillance, Epidemiology, and End Results (SEER) Residual Tissue Repositories Program by using polymerase chain reaction and genotyping (Inno-LiPA), HPV16 viral load, and HPV16 mRNA expression. Trends in HPV prevalence across four calendar periods were estimated by using logistic regression. Observed HPV prevalence was reweighted to all oropharyngeal cancers…
Citation impact
- FWCI
- 138.77
- Percentile
- 100%
- References
- 36
Authors
18- AKAnil K. ChaturvediCorresponding
National Cancer Institute
- EAEric A. Engels
University of Southern California, University of Iowa, National Institutes of Health, Cancer Center of Hawaii, National Cancer Institute, Cancer Research Center, National Cancer Institute, The Ohio State University
- RMRuth M. Pfeiffer
University of Southern California, University of Iowa, National Institutes of Health, Cancer Center of Hawaii, National Cancer Institute, Cancer Research Center, National Cancer Institute, The Ohio State University
- BYBrenda Y. Hernandez
University of Southern California, University of Iowa, National Institutes of Health, Cancer Center of Hawaii, National Cancer Institute, Cancer Research Center, National Cancer Institute, The Ohio State University
- WXWeihong Xiao
University of Southern California, University of Iowa, National Institutes of Health, Cancer Center of Hawaii, National Cancer Institute, Cancer Research Center, National Cancer Institute, The Ohio State University
Topics & keywords
- Medicine
- Incidence (geometry)
- Epidemiology
- Internal medicine
- Human papillomavirus
- Population
- Proportional hazards model
- Oncology
- Good health and well-being