Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein
University of California San Diego · Moores Cancer Center · +2 more institutions
Abstract
The Yes-associated protein (YAP) is a transcription coactivator that plays a crucial role in organ size control by promoting cell proliferation and inhibiting apoptosis. The Hippo tumor suppressor pathway inhibits YAP through phosphorylation-induced cytoplasmic retention and degradation. Here we report a novel mechanism of YAP regulation by angiomotin (AMOT) family proteins via a direct interaction. Knockdown of AMOT family protein AMOTL2 in polarized Madin-Darby canine kidney (MDCK) cells leads to YAP activation, as indicated by decreased YAP tight junction localization, attenuated YAP phosphorylation, accumulation of nuclear YAP, and induction of YAP target gene expression. Transcriptional coactivator with…
Citation impact
- FWCI
- —
- Percentile
- —
- References
- 51
Authors
7- BZBin ZhaoCorresponding
University of California San Diego, Moores Cancer Center
- LLLi Li
University of Michigan, University of California San Diego, Moores Cancer Center
- QRQ. Richard Lu
University of California San Diego, Moores Cancer Center
- LHLloyd H. Wang
University of California San Diego, Moores Cancer Center
- CLChen‐Ying Liu
Fudan University
Topics & keywords
- Hippo signaling pathway
- Biology
- Gene knockdown
- Coactivator
- Cell biology
- Phosphorylation
- Contact inhibition
- Transcription factor
- Good health and well-being