Clinical and Biological Features Associated With Epidermal Growth Factor Receptor Gene Mutations in Lung Cancers
The University of Texas MD Anderson Cancer Center · Fred Hutch Cancer Center · +5 more institutions
Abstract
Mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene in lung cancers are associated with increased sensitivity of these cancers to drugs that inhibit EGFR kinase activity. However, the role of such mutations in the pathogenesis of lung cancers is unclear.
We sequenced exons 18-21 of the EGFR TK domain from genomic DNA isolated from 617 non-small-cell lung cancers (NSCLCs) and 524 normal lung tissue samples from the same patients and 36 neuroendocrine lung tumors collected from patients in Japan, Taiwan, the United States, and Australia and from 243 other epithelial cancers. Mutation status was compared with clinicopathologic features and with the presence of mutations in KRAS, a gene in the EGFR signaling pathway that is also frequently mutated in lung cancers. All statistical tests were two sided.
Citation impact
- FWCI
- 122.54
- Percentile
- 100%
- References
- 44
Authors
16- HSHisayuki ShigematsuCorresponding
The University of Texas MD Anderson Cancer Center, Fred Hutch Cancer Center, The University of Texas Southwestern Medical Center, Chung Shan Medical University, Okayama University, Chiba University, Prince Charles Hospital
- LLLin Li
Chiba University, The University of Texas Southwestern Medical Center, Okayama University, The University of Texas MD Anderson Cancer Center, Prince Charles Hospital, Chung Shan Medical University, Fred Hutch Cancer Center
- TTTsuyoshi Takahashi
Okayama University, The University of Texas Southwestern Medical Center, Chung Shan Medical University, Chiba University, The University of Texas MD Anderson Cancer Center, Fred Hutch Cancer Center, Prince Charles Hospital
- MNMasatoshi Nomura
Okayama University, The University of Texas Southwestern Medical Center, Chiba University, Prince Charles Hospital, Fred Hutch Cancer Center, Chung Shan Medical University, The University of Texas MD Anderson Cancer Center
- MSM. Suzuki
Fred Hutch Cancer Center, Prince Charles Hospital, Chung Shan Medical University, Okayama University, Chiba University, The University of Texas MD Anderson Cancer Center, The University of Texas Southwestern Medical Center
Topics & keywords
- Epidermal growth factor receptor
- KRAS
- Lung cancer
- Lung
- Cancer research
- Medicine
- Mutation
- Epidermal growth factor
- Good health and well-being