Overexpression of Monocyte Chemoattractant Protein-1 in Adipose Tissues Causes Macrophage Recruitment and Insulin Resistance
Hiroshima University · The University of Tokyo · +6 more institutions
Abstract
Adipose tissue expression and circulating concentrations of monocyte chemoattractant protein-1 (MCP-1) correlate positively with adiposity. To ascertain the roles of MCP-1 overexpression in adipose, we generated transgenic mice by utilizing the adipocyte P2 (aP2) promoter (aP2-MCP-1 mice). These mice had higher plasma MCP-1 concentrations and increased macrophage accumulation in adipose tissues, as confirmed by immunochemical, flow cytometric, and gene expression analyses. Tumor necrosis factor-alpha and interleukin-6 mRNA levels in white adipose tissue and plasma non-esterified fatty acid levels were increased in transgenic mice. aP2-MCP-1 mice showed insulin resistance, suggesting that inflammatory changes…
Citation impact
- FWCI
- 32.93
- Percentile
- 100%
- References
- 45
Authors
24- NKNozomu Kamei
Hiroshima University, The University of Tokyo
- KTKazuyuki Tobe
Japan Science and Technology Agency, The University of Tokyo
- RSRyo Suzuki
Japan Science and Technology Agency, The University of Tokyo
- MOMitsuru Ohsugi
Central Institute for Experimental Animals, The University of Tokyo
- TWTaku Watanabe
Central Institute for Experimental Animals, The University of Tokyo
Topics & keywords
- Internal medicine
- Adipose tissue
- Endocrinology
- Insulin resistance
- Adipose tissue macrophages
- Monocyte
- White adipose tissue
- Biology