articleJournal of Clinical OncologyMay 15, 2012BRONZE OA

Updated Analysis of SWOG-Directed Intergroup Study 0116: A Phase III Trial of Adjuvant Radiochemotherapy Versus Observation After Curative Gastric Cancer Resection

SRStephen R. SmalleyJBJacqueline BenedettiDGDaniel G. HallerSAScott A. HundahlNENorman Estes

Fred Hutch Cancer Center · Mayo Clinic in Arizona · +2 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

PURPOSE: Surgical resection of gastric cancer has produced suboptimal survival despite multiple randomized trials that used postoperative chemotherapy or more aggressive surgical procedures. We performed a randomized phase III trial of postoperative radiochemotherapy in those at moderate risk of locoregional failure (LRF) following surgery. We originally reported results with 4-year median follow-up. This update, with a more than 10-year median follow-up, presents data on failure patterns and second malignancies and explores selected subset analyses. PATIENTS AND METHODS: In all, 559 patients with primaries ≥ T3 and/or node-positive gastric cancer were randomly assigned to observation versus radiochemotherapy…

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Topics & keywords

Topics
Keywords
  • Medicine
  • Hazard ratio
  • Radiation therapy
  • Internal medicine
  • Cancer
  • Randomized controlled trial
  • Chemotherapy
  • Oncology
UN Sustainable Development Goals
  • Good health and well-being
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