Antiinflammatory Properties of HDL
University of California, Los Angeles · University of Alabama · +1 more institution
Abstract
There are several well-documented functions of high-density lipoprotein (HDL) that may explain the ability of these lipoproteins to protect against atherosclerosis. The best recognized of these is the ability of HDL to promote the efflux of cholesterol from cells. This process may minimize the accumulation of foam cells in the artery wall. However, HDL has additional properties that may also be antiatherogenic. For example, HDL is an effective antioxidant. The major proteins of HDL, apoA-I and apoA-II, as well as other proteins such as paraoxonase that cotransport with HDL in plasma, are well-known to have antioxidant properties. As a consequence, HDL has the capacity to inhibit the oxidative modification of…
Citation impact
- FWCI
- 36.37
- Percentile
- 100%
- References
- 175
Authors
6- PJPhilip J. BarterCorresponding
University of California, Los Angeles, University of Alabama, University of California System
- SJStephen J. Nicholls
University of California, Los Angeles, University of Alabama, University of California System
- KRKerry-Anne Rye
University of California, Los Angeles, University of Alabama, University of California System
- GAG.M. Anantharamaiah
University of California, Los Angeles, University of Alabama, University of California System
- MNMohamad Navab
University of California, Los Angeles, University of Alabama, University of California System
Topics & keywords
- High-density lipoprotein
- Lipoprotein
- Antioxidant
- Cholesterol
- Chemistry
- Paraoxonase
- Efflux
- ABCA1