Metabolite Profiling Identifies Pathways Associated With Metabolic Risk in Humans
Broad Institute · Boston University · +4 more institutions
Abstract
BACKGROUND: Although metabolic risk factors are known to cluster in individuals who are prone to developing diabetes mellitus and cardiovascular disease, the underlying biological mechanisms remain poorly understood. METHODS AND RESULTS: To identify pathways associated with cardiometabolic risk, we used liquid chromatography/mass spectrometry to determine the plasma concentrations of 45 distinct metabolites and to examine their relation to cardiometabolic risk in the Framingham Heart Study (FHS; n=1015) and the Malmö Diet and Cancer Study (MDC; n=746). We then interrogated significant findings in experimental models of cardiovascular and metabolic disease. We observed that metabolic risk factors (obesity,…
Citation impact
- FWCI
- 14.91
- Percentile
- 100%
- References
- 45
Authors
19- SCSusan ChengCorresponding
Broad Institute, Boston University, Brigham and Women's Hospital, Harvard University, National Heart Lung and Blood Institute, Framingham Heart Study
- EPEugene P. Rhee
Broad Institute, Boston University, Brigham and Women's Hospital, Harvard University, National Heart Lung and Blood Institute, Framingham Heart Study
- MGMartin G. Larson
Broad Institute, Boston University, Brigham and Women's Hospital, Harvard University, National Heart Lung and Blood Institute, Framingham Heart Study
- GDGregory D. Lewis
Broad Institute, Boston University, Brigham and Women's Hospital, Harvard University, National Heart Lung and Blood Institute, Framingham Heart Study
- ELElizabeth L. McCabe
Broad Institute, Boston University, Brigham and Women's Hospital, Harvard University, National Heart Lung and Blood Institute, Framingham Heart Study
Topics & keywords
- Glutamine
- Medicine
- Insulin resistance
- Internal medicine
- Endocrinology
- Diabetes mellitus
- Dyslipidemia
- Metabolite
- Good health and well-being