The Influence of CCL3L1 Gene-Containing Segmental Duplications on HIV-1/AIDS Susceptibility
The University of Texas at San Antonio Health Science Center · Garrahan Hospital · +6 more institutions
Abstract
Segmental duplications in the human genome are selectively enriched for genes involved in immunity, although the phenotypic consequences for host defense are unknown. We show that there are significant interindividual and interpopulation differences in the copy number of a segmental duplication encompassing the gene encoding CCL3L1 (MIP-1alphaP), a potent human immunodeficiency virus-1 (HIV-1)-suppressive chemokine and ligand for the HIV coreceptor CCR5. Possession of a CCL3L1 copy number lower than the population average is associated with markedly enhanced HIV/acquired immunodeficiency syndrome (AIDS) susceptibility. This susceptibility is even greater in individuals who also possess disease-accelerating…
Citation impact
- FWCI
- 36.92
- Percentile
- 100%
- References
- 25
Authors
22- EAEnrique A. GonzálezCorresponding
The University of Texas at San Antonio Health Science Center, Garrahan Hospital, Beatson West of Scotland Cancer Centre, Cancer Research UK, Cancer Research UK Scotland Institute, South Texas Veterans Health Care System, Wake Forest University
- HKHemant KulkarniCorresponding
The University of Texas at San Antonio Health Science Center, Garrahan Hospital, Beatson West of Scotland Cancer Centre, Cancer Research UK, Cancer Research UK Scotland Institute, South Texas Veterans Health Care System, Wake Forest University
- HBHéctor BolívarCorresponding
The University of Texas at San Antonio Health Science Center, Garrahan Hospital, Beatson West of Scotland Cancer Centre, Cancer Research UK, Cancer Research UK Scotland Institute, South Texas Veterans Health Care System, Wake Forest University
- AMAndrea ManganoCorresponding
The University of Texas at San Antonio Health Science Center, Garrahan Hospital, Beatson West of Scotland Cancer Centre, Cancer Research UK, Cancer Research UK Scotland Institute, South Texas Veterans Health Care System, Wake Forest University
- RSRacquel SanchezCorresponding
The University of Texas at San Antonio Health Science Center, Garrahan Hospital, Beatson West of Scotland Cancer Centre, Cancer Research UK, Cancer Research UK Scotland Institute, South Texas Veterans Health Care System, Wake Forest University
Topics & keywords
- Biology
- Gene duplication
- Gene
- Genetics
- Immunology
- Population
- Phenotype
- Virology
- Good health and well-being