Peptide stapling techniques based on different macrocyclisation chemistries
University of Cambridge · NOAA Chemical Sciences Laboratory
Abstract
Peptide stapling is a strategy for constraining short peptides typically in an alpha-helical conformation. Stapling is carried out by covalently linking the side-chains of two amino acids, thereby forming a peptide macrocycle. There is an expanding repertoire of stapling techniques based on different macrocyclisation chemistries. In this tutorial review, we categorise and analyse key examples of peptide stapling in terms of their synthesis and applicability to biological systems.
Citation impact
- FWCI
- 16.64
- Percentile
- 100%
- References
- 48
Authors
4- YHYu Heng Lau
University of Cambridge, NOAA Chemical Sciences Laboratory
- PDPeterson de Andrade
University of Cambridge, NOAA Chemical Sciences Laboratory
- YWYuteng Wu
University of Cambridge, NOAA Chemical Sciences Laboratory
- DRDavid R. SpringCorresponding
University of Cambridge, NOAA Chemical Sciences Laboratory
Topics & keywords
- Chemistry
- Peptide
- Nanotechnology
- Combinatorial chemistry
- Biochemistry
- Materials science
- Zero hunger