The early spread and epidemic ignition of HIV-1 in human populations
Rega Institute for Medical Research · University of Oxford · +13 more institutions
Abstract
Thirty years after the discovery of HIV-1, the early transmission, dissemination, and establishment of the virus in human populations remain unclear. Using statistical approaches applied to HIV-1 sequence data from central Africa, we show that from the 1920s Kinshasa (in what is now the Democratic Republic of Congo) was the focus of early transmission and the source of pre-1960 pandemic viruses elsewhere. Location and dating estimates were validated using the earliest HIV-1 archival sample, also from Kinshasa. The epidemic histories of HIV-1 group M and nonpandemic group O were similar until ~1960, after which group M underwent an epidemiological transition and outpaced regional population growth. Our results…
Citation impact
- FWCI
- 33.49
- Percentile
- 100%
- References
- 93
Authors
14- NRNuno R. FariaCorresponding
Rega Institute for Medical Research, University of Oxford
- ARAndrew Rambaut
National Institutes of Health, Centre for Immunity, Infection and Evolution, Fogarty International Center, University of Edinburgh
- MAMarc A. Suchard
University of California, Los Angeles
- GBGuy Baele
Rega Institute for Medical Research
- TBTrevor Bedford
Fred Hutch Cancer Center
Topics & keywords
- Transmission (telecommunications)
- Pandemic
- Population
- Human immunodeficiency virus (HIV)
- Demography
- Geography
- Epidemiological transition
- Epidemiology
- Good health and well-being