reviewJournal of Bone and Mineral ResearchOct 24, 2015BRONZE OA

A Meta-Analysis of Trabecular Bone Score in Fracture Risk Prediction and Its Relationship to FRAX

EMEugène McCloskeyAOAnders OdénNCNicholas C. HarveyWDWilliam D. LeslieDHDidier Hans

University of Sheffield · MRC Lifecourse Epidemiology Unit · +27 more institutions

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Abstract

Trabecular bone score (TBS) is a gray-level textural index of bone microarchitecture derived from lumbar spine dual-energy X-ray absorptiometry (DXA) images. TBS is a bone mineral density (BMD)-independent predictor of fracture risk. The objective of this meta-analysis was to determine whether TBS predicted fracture risk independently of FRAX probability and to examine their combined performance by adjusting the FRAX probability for TBS. We utilized individual-level data from 17,809 men and women in 14 prospective population-based cohorts. Baseline evaluation included TBS and the FRAX risk variables, and outcomes during follow-up (mean 6.7 years) comprised major osteoporotic fractures. The association between…

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Topics & keywords

Topics
Keywords
  • FRAX
  • Trabecular bone score
  • Medicine
  • Osteoporosis
  • Cohort
  • Hazard ratio
  • Bone mineral
  • Confidence interval
UN Sustainable Development Goals
  • Good health and well-being
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