FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
Beth Israel Deaconess Medical Center · Harvard University · +3 more institutions
Abstract
Certain white adipose tissue (WAT) depots are readily able to convert to a "brown-like" state with prolonged cold exposure or exposure to β-adrenergic compounds. This process is characterized by the appearance of pockets of uncoupling protein 1 (UCP1)-positive, multilocular adipocytes and serves to increase the thermogenic capacity of the organism. We show here that fibroblast growth factor 21 (FGF21) plays a physiologic role in this thermogenic recruitment of WATs. In fact, mice deficient in FGF21 display an impaired ability to adapt to chronic cold exposure, with diminished browning of WAT. Adipose-derived FGF21 acts in an autocrine/paracrine manner to increase expression of UCP1 and other thermogenic genes…
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Authors
11- FMFfolliott M. FisherCorresponding
Beth Israel Deaconess Medical Center, Harvard University
- SKSandra Kleiner
Harvard University, Dana-Farber Cancer Institute, Institute of Cell Biology
- NDNicholas Douris
Beth Israel Deaconess Medical Center, Harvard University
- ECElliott C. Fox
Beth Israel Deaconess Medical Center, Harvard University
- RJRina J. Mepani
Harvard University, Dana-Farber Cancer Institute, Institute of Cell Biology
Topics & keywords
- FGF21
- Biology
- Thermogenesis
- White adipose tissue
- Adipose tissue
- Thermogenin
- PRDM16
- Paracrine signalling