Whole-Genome Patterns of Common DNA Variation in Three Human Populations
International Computer Science Institute · University of California San Diego
Abstract
Individual differences in DNA sequence are the genetic basis of human variability. We have characterized whole-genome patterns of common human DNA variation by genotyping 1,586,383 single-nucleotide polymorphisms (SNPs) in 71 Americans of European, African, and Asian ancestry. Our results indicate that these SNPs capture most common genetic variation as a result of linkage disequilibrium, the correlation among common SNP alleles. We observe a strong correlation between extended regions of linkage disequilibrium and functional genomic elements. Our data provide a tool for exploring many questions that remain regarding the causal role of common human DNA variation in complex human traits and for investigating…
Citation impact
- FWCI
- 125.32
- Percentile
- 100%
- References
- 37
Authors
8- DADavid A. Hinds
International Computer Science Institute, University of California San Diego
- LLLaura L. Stuvé
International Computer Science Institute, University of California San Diego
- GBGeoffrey B. Nilsen
International Computer Science Institute, University of California San Diego
- EHEran Halperin
International Computer Science Institute, University of California San Diego
- EEEleazar Eskin
International Computer Science Institute, University of California San Diego
Topics & keywords
- Linkage disequilibrium
- Biology
- Single-nucleotide polymorphism
- Genetics
- Human genetic variation
- Human genome
- Genetic variation
- SNP genotyping