reviewThe Annual Review of Pharmacology and ToxicologyNov 2, 2004GREEN OA

PLEIOTROPIC EFFECTS OF STATINS

JKJames K. LiaoULUlrich Laufs

Brigham and Women's Hospital · Saarland University

PubMed
Indexed incrossrefpubmed

Abstract

Statins are potent inhibitors of cholesterol biosynthesis. In clinical trials, statins are beneficial in the primary and secondary prevention of coronary heart disease. However, the overall benefits observed with statins appear to be greater than what might be expected from changes in lipid levels alone, suggesting effects beyond cholesterol lowering. Indeed, recent studies indicate that some of the cholesterol-independent or "pleiotropic" effects of statins involve improving endothelial function, enhancing the stability of atherosclerotic plaques, decreasing oxidative stress and inflammation, and inhibiting the thrombogenic response. Furthermore, statins have beneficial extrahepatic effects on the immune…

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1,955
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58.30
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100%
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Authors

2

Topics & keywords

Topics
Keywords
  • Prenylation
  • Cholesterol
  • Inflammation
  • Oxidative stress
  • Pharmacology
  • Statin
  • Immune system
  • Chemistry
UN Sustainable Development Goals
  • Good health and well-being
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