articleMolecular Systems BiologySep 25, 2012GOLD OA

Novel biomarkers for pre‐diabetes identified by metabolomics

RWRui Wang‐SattlerZYZhonghao YuCHChristian HerderACAna C. MessiasAFAnna Floegel

Helmholtz Zentrum München · Deutsches Diabetes-Zentrum e.V. · +19 more institutions

PubMed
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Abstract

Type 2 diabetes (T2D) can be prevented in pre-diabetic individuals with impaired glucose tolerance (IGT). Here, we have used a metabolomics approach to identify candidate biomarkers of pre-diabetes. We quantified 140 metabolites for 4297 fasting serum samples in the population-based Cooperative Health Research in the Region of Augsburg (KORA) cohort. Our study revealed significant metabolic variation in pre-diabetic individuals that are distinct from known diabetes risk indicators, such as glycosylated hemoglobin levels, fasting glucose and insulin. We identified three metabolites (glycine, lysophosphatidylcholine (LPC) (18:2) and acetylcarnitine) that had significantly altered levels in IGT individuals as…

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Topics & keywords

Topics
Keywords
  • European Prospective Investigation into Cancer and Nutrition
  • Type 2 diabetes
  • Biology
  • Metabolomics
  • Metabolite
  • Diabetes mellitus
  • Impaired glucose tolerance
  • Internal medicine
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